Peer-Reviewed Publications

Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry.
Tata A, Woolman M, Ventura M, Bernards N, Ganguly M, Gribble A, Shrestha B, Bluemke E, Ginsberg HJ, Vitkin A, Zheng J, Zarrine-Afsar A.
Sci Rep. 2016 Oct 13;6:35374. doi: 10.1038/srep35374.
PMID: 27734938

Multi-Modal Imaging in a Mouse Model of Orthotopic Lung Cancer.
Patel P, Kato T, Ujiie H, Wada H, Lee D, Hu HP, Hirohashi K, Ahn JY, Zheng J, Yasufuku K.
PLoS One. 2016 Sep 1;11(9):e0161991. doi: 10.1371/journal.pone.0161991.
PMID: 27584018

Spatial Measurements of Perfusion, Interstitial Fluid Pressure and Liposomes Accumulation in Solid Tumors.
Stapleton S, Mirmilshteyn D, Zheng J, Allen C, Jaffray DA.
J Vis Exp. 2016 Aug 18;(114). doi: 10.3791/54226.
PMID: 27583578

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance.
Dou YN, Weersink RA, Foltz WD, Zheng J, Chaudary N, Jaffray DA, Allen C.
J Vis Exp. 2015 Dec 13;(106). doi: 10.3791/53055.
PMID: 26709539

Ambient Mass Spectrometry Imaging with Picosecond Infrared Laser Ablation Electrospray Ionization (PIR-LAESI).
Zou J, Talbot F, Tata A, Ermini L, Franjic K, Ventura M, Zheng J, Ginsberg H, Post M, Ifa DR, Jaffray D, Miller RJ, Zarrine-Afsar A.
Anal Chem. 2015 Dec 15;87(24):12071-9. doi: 10.1021/acs.analchem.5b02756. Epub 2015 Nov 23.
PMID: 26561279

Longitudinal tumor hypoxia imaging with [(18)F]FAZA-PET provides early prediction of nanoliposomal irinotecan (nal-IRI) treatment activity.
Zheng J, Klinz SG, De Souza R, Fitzgerald J, Jaffray DA.
EJNMMI Res. 2015 Dec;5(1):57. doi: 10.1186/s13550-015-0135-x. Epub 2015 Oct 19.
PMID: 26481012 Free PMC Article

A multimodal nano agent for image-guided cancer surgery.
Zheng J, Muhanna N, De Souza R, Wada H, Chan H, Akens MK, Anayama T, Yasufuku K, Serra S, Irish J, Allen C, Jaffray D.
Biomaterials. 2015 Oct;67:160-8. doi: 10.1016/j.biomaterials.2015.07.010. Epub 2015 Jul 14.
PMID: 26218742 Free Article

Evaluation of PET Imaging Performance of the TSPO Radioligand [(18)F]DPA-714 in Mouse and Rat Models of Cancer and Inflammation.
Zheng J, Winkeler A, Peyronneau MA, Dollé F, Boisgard R.
Mol Imaging Biol. 2016 Feb;18(1):127-34. doi: 10.1007/s11307-015-0877-x.
PMID: 26194010 Free PMC Article

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302).
Geretti E, Leonard SC, Dumont N, Lee H, Zheng J, De Souza R, Gaddy DF, Espelin CW, Jaffray DA, Moyo V, Nielsen UB, Wickham TJ, Hendriks BS.
Mol Cancer Ther. 2015 Sep;14(9):2060-71. doi: 10.1158/1535-7163.MCT-15-0314. Epub 2015 Jul 10.
PMID: 26162690

Contrast Agent Mass Spectrometry Imaging Reveals Tumor Heterogeneity.
Tata A, Zheng J, Ginsberg HJ, Jaffray DA, Ifa DR, Zarrine-Afsar A.
Anal Chem. 2015 Aug 4;87(15):7683-9. doi: 10.1021/acs.analchem.5b01992. Epub 2015 Jul 15.
PMID: 26138213

Whole-body organ-level and kidney micro-dosimetric evaluations of (64)Cu-loaded HER2/ErbB2-targeted liposomal doxorubicin ((64)Cu-MM-302) in rodents and primates.
Gaddy DF, Lee H, Zheng J, Jaffray DA, Wickham TJ, Hendriks BS.
EJNMMI Res. 2015 Apr 14;5:24. doi: 10.1186/s13550-015-0096-0. eCollection 2015.
PMID: 25918676 Free PMC Article

A gradient-loadable (64)Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography.
Lee H, Zheng J, Gaddy D, Orcutt KD, Leonard S, Geretti E, Hesterman J, Harwell C, Hoppin J, Jaffray DA, Wickham T, Hendriks BS, Kirpotin D.
Nanomedicine. 2015 Jan;11(1):155-65. doi: 10.1016/j.nano.2014.08.011. Epub 2014 Sep 6.
PMID: 25200610

Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice.
Dou YN, Zheng J, Foltz WD, Weersink R, Chaudary N, Jaffray DA, Allen C.
J Control Release. 2014 Mar 28;178:69-78. doi: 10.1016/j.jconrel.2014.01.009. Epub 2014 Jan 15.
PMID: 24440663

A mathematical model of the enhanced permeability and retention effect for liposome transport in solid tumors.
Stapleton S, Milosevic M, Allen C, Zheng J, Dunne M, Yeung I, Jaffray DA.
PLoS One. 2013 Dec 2;8(12):e81157. doi: 10.1371/journal.pone.0081157. eCollection 2013.
PMID: 24312530 Free PMC Article

The translocator protein radioligand 18F-DPA-714 monitors antitumor effect of erufosine in a rat 9L intracranial glioma model.
Awde AR, Boisgard R, Thézé B, Dubois A, Zheng J, Dollé F, Jacobs AH, Tavitian B, Winkeler A.
J Nucl Med. 2013 Dec;54(12):2125-31. doi: 10.2967/jnumed.112.118794. Epub 2013 Nov 8.
PMID: 24212976 Free Article

A novel minimally invasive technique to create a rabbit VX2 lung tumor model for nano-sized image contrast and interventional studies.
Anayama T, Nakajima T, Dunne M, Zheng J, Allen C, Driscoll B, Vines D, Keshavjee S, Jaffray D, Yasufuku K.
PLoS One. 2013 Jun 28;8(6):e67355. doi: 10.1371/journal.pone.0067355. Print 2013.
PMID: 23840673 Free PMC Article

The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo.
Winkeler A, Boisgard R, Awde AR, Dubois A, Thézé B, Zheng J, Ciobanu L, Dollé F, Viel T, Jacobs AH, Tavitian B.
Eur J Nucl Med Mol Imaging. 2012 May;39(5):811-23. doi: 10.1007/s00259-011-2041-4. Epub 2012 Jan 21.
PMID: 22270507 Free PMC Article

PEGylated liposome co-encapsulating iohexol and gadoteridol for multimodal CT and MR imaging.
Zheng J, Allen C, Jaffray D, Chopra A.
Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013.
2011 Jul 29 [updated 2011 Sep 29].
PMID: 21977536 Free Books & Documents

APN/CD13-targeting as a strategy to alter the tumor accumulation of liposomes.
Dunne M, Zheng J, Rosenblat J, Jaffray DA, Allen C.
J Control Release. 2011 Sep 25;154(3):298-305. doi: 10.1016/j.jconrel.2011.05.022. Epub 2011 May 27.
PMID: 21640146

Differential expression of the 18 kDa translocator protein (TSPO) by neoplastic and inflammatory cells in mouse tumors of breast cancer.
Zheng J, Boisgard R, Siquier-Pernet K, Decaudin D, Dollé F, Tavitian B.
Mol Pharm. 2011 Jun 6;8(3):823-32. doi: 10.1021/mp100433c. Epub 2011 Apr 4.
PMID: 21417480

Liposome contrast agent for CT-based detection and localization of neoplastic and inflammatory lesions in rabbits: validation with FDG-PET and histology.
Zheng J, Allen C, Serra S, Vines D, Charron M, Jaffray DA.
Contrast Media Mol Imaging. 2010 May-Jun;5(3):147-54. doi: 10.1002/cmmi.378.
PMID: 20586032

Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.
Schwock J, Dhani N, Cao MP, Zheng J, Clarkson R, Radulovich N, Navab R, Horn LC, Hedley DW.
Cancer Res. 2009 Jun 1;69(11):4750-9. doi: 10.1158/0008-5472.CAN-09-0454. Epub 2009 May 19.
PMID: 19458065

Quantitative CT imaging of the spatial and temporal distribution of liposomes in a rabbit tumor model.
Zheng J, Jaffray D, Allen C.
Mol Pharm. 2009 Mar-Apr;6(2):571-80. doi: 10.1021/mp800234r.
PMID: 19298061

In vivo performance of a liposomal vascular contrast agent for CT and MR-based image guidance applications.
Zheng J, Liu J, Dunne M, Jaffray DA, Allen C.
Pharm Res. 2007 Jun;24(6):1193-201. Epub 2007 Mar 21.
PMID: 17373581

Multimodal contrast agent for combined computed tomography and magnetic resonance imaging applications.
Zheng J, Perkins G, Kirilova A, Allen C, Jaffray DA.
Invest Radiol. 2006 Mar;41(3):339-48.
PMID: 16481918

Book Chapters

The Role of Imaging in Nanomedicine Development and Clinical Translation.
Book title: Nanomedicines: Design, Delivery and Detection.
Zheng J, De Souza R, Ventura M, Allen C, Jaffray DA.
Editor: Dr. Martin Braddock. Publisher: Royal Society of Chemistry Publishing, Thomas Graham House, Mar 2016.

Nanotechnology for Multimodality Imaging: Applications in Disease Detection and Treatment Guidance.
Book title: Frontiers of Nanobiomedical Research: Handbook of Nanobiomedical Research.
Zheng J, De Souza R, Jaffray DA and Allen C.
Editor: Vladimir Tochilin. Publisher: World Scientific Publishing, Oct 2014.

Long Circulation and Tumor Accumulation.
Book Title: Cancer Targeted Drug Delivery: An Elusive Dream.
Ekdawi SN, Mikhail AS, Stapleton S, Zheng J, Eetezadi S, Jaffray DA, Allen C.
Editors: You Han Bae, Randall Mrsny and Kinam Park. Publisher: Springer, 2013.

Nano-medicines Coming of Age – Recent Developments in Nano-Neuroscience and Nano-Oncology.
Book Title: Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, Volume 2.
Savic R, Zheng J, Allen C, Maysinger D.
Editors: Severian Dumitriu and Valentin Popa. Publisher: CRC Press – Taylor and Francis group, Jan 17, 2013.

Nanosystems for Multimodality in vivo Imaging.
Book title: Multifunctional Pharmaceutical Nanocarriers.
Zheng J, Jaffray DA, Allen C.
Editor: Vladimir Torchilin. Publisher: Springer New York, 2008.